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7. ”Anabolic” refers to tissue building (mainly muscle), and ”androgenic”
   refers to a group of intercourse hormones known as androgens.
   Testosterone performs a vital role not only in building muscle
   mass but also in burning calories effectively. This naturally occurring compound is integral to enhancing physical activity ranges, improving mood, intercourse drive, cognitive perform, and total quality of life.
   For newcomers to steroid use, starting with a shorter cycle—such as four weeks—followed by a 6-week off-cycle is advisable.

   Relying on the half-life of a steroid to determine your drug take a look at risk is,
   therefore, a great mistake. Only probably the most fundamental
   of drug testing will search for the steroid hormone itself somewhat than its metabolites.
   These intramuscular injections ensure the solution is entered deep into the muscle, which
   may travel steadily and safely via smaller veins quite than being placed immediately into the bloodstream.
   The steroids are shortly absorbed, and fast-acting steroids can begin working as soon as you expect them to.

   AAS Pharmacy is widely known for selling high-quality anabolic steroids with comprehensive product information for every
   merchandise. With clear dosage pointers and descriptions, AAS Pharmacy aims to make
   every buy clear and simple. The website additionally prioritizes person privateness, providing safe fee methods and discreet transport
   options. Remember, the responsible use of Anavar goes hand in hand with appropriate dosages, cycle
   lengths, and post-cycle therapy (PCT) protocols. Monitoring your body’s response, managing potential unwanted effects,
   and prioritizing total well-being are key features of using Anavar safely and effectively.
   By making knowledgeable selections, seeking steering, and following
   greatest practices, you probably can optimize your Anavar
   experience and work towards achieving your required health and efficiency goals.

   If you’ve an opposed reaction while using these products,
   contact your health care practitioner immediately.
   Consumers and health care practitioners are additionally inspired
   to inform Health Canada about adverse reactions
   through the MedEffect Web website. Use anaboic steroids will
   cause certain side effects, individuals imagine that by taking the steroids within the an accurate method will assist them to avoid pointless unwanted
   facet effects.
   This can be a large saving when buying in bulk, as if you purchase 8 bottles, you’ll obtain four free (which is
   up to four months’ worth of free products). Hair loss,
   pimples, mood swings, liver pressure, and testosterone shutdown are common. This proves
   the product is dosed correctly and freed from dangerous
   contaminants.
   If you’re going to do recurring cycles, your off-cycle time must be no less than equal
   to the size of the cycle itself. This permits a full HPTA restoration (aided by
   PCT) and a sufficient break from all steroids before getting again to a different cycle.
   This technique speeds up your pure testosterone recovery and supplies
   a good cause why utilizing HCG on-cycle is so beneficial!
   Put simply, the usage of HCG following one of many above strategies ensures you begin recovering your testosterone production as soon as you begin your PCT.
   Equipoise has the added benefits of boosting the urge for food and enhancing stamina, vascularity, and pumps.

   Take this quick quiz — we’ll advocate basic cycle tailored to
   your gender, age, and health objectives (muscle gain, fat loss, endurance, etc.).
   You must also stick to the conservative dosages
   for the steroid you are using. One of the principle causes that bodybuilders end
   up with well being problems from steroid use is that they massively overdose
   on the quantities. These Days the common man on the road takes their steroids in quantities that the Professionals of ten years would never have dreamed
   of taking! There’s no denying that Testosterone is a good drug for muscle
   constructing.
   When assessing a product web page, search for consistent labeling, batch details, and clear usage notes (serving measurement, storage,
   and general guidance). A sturdy example is Dragon Pharma Testosterone Cypionate 250 mg—a branded itemizing that illustrates how skilled packaging, verified composition, and straight-forward specs come together to
   inspire confidence.

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8. These activities combine to make Deca a strong lean muscle builder – even if not some of the potent bulking
   steroids out there. Muscle features with the slow-acting Nandrolone decanoate take time to develop, and
   users shouldn’t expect notable positive aspects inside the
   first weeks of a cycle. A cycle size of no less than 12 weeks is required
   to get the maximum benefit from this steroid.
   Anavar can also exacerbate pre-existing circumstances, similar to coronary heart
   disease or liver issues. It’s crucial to assume
   about these risks and discuss them with a healthcare skilled before starting Anavar.
   Hair thinning or increased male-pattern baldness in predisposed
   individuals is another potential side effect.

   Liver harm, additionally known as hepatotoxicity, can happen when taking oxandrolone.
   In rare instances, some folks have had liver tumors or blood-filled cysts in the liver and/or spleen. Name your well being
   care supplier instantly in case you have any of the next
   symptoms of liver injury. Generally, AAS affects
   the metabolism of an individual and the way fat
   deposits within the body. Ultimately, when one makes use of these medicine, fat shall be deposited to
   the abdomen, face, and neck, causing weight gain.
   Athletes might take steroids for a sure interval, cease, then start once more several times a 12 months.
   Athletes additionally often use many steroids at the same time (a
   practice known as stacking), they usually take them by totally different
   routes (by mouth, injection, or patch). Cycling,
   stacking, and pyramiding are meant to enhance desired effects and reduce harmful results, however little proof supports these benefits.
   Many individuals who use anabolic steroids recreationally take far more than is usually used for
   medical circumstances. This is very true if the steroids
   are in a complement or injection that incorporates excessive concentrations.
   Technically called anabolic-androgenic steroids (AASs), steroids
   are a type of artificial testosterone. They can be taken as a supplement to replace
   or add to your body’s pure levels of testosterone.

   Notably, renal histopathological adjustments were extra
   pronounced six weeks after discontinuing androgens, indicating that issues could persist even after the use is discontinued (Kahal
   and Allem, 2018). This susceptibility appears to correlate
   with the dosage and efficiency of artificial compounds (Socas et al.,
   2005). AAS induces intracellular androgenic actions that stimulate gene cascades important for cellular homeostasis.

   She hopes that at some point her research and advocacy will help to save the lives of those who have been affected by substance use.

   She likes to say that advocacy is her ardour and leadership is her superpower.
   Nicki has earned a Grasp of Science degree in Psychology with an emphasis
   in Behavioral Health from the University of Phoenix and a Grasp of Science in Professional Counseling from Grand Canyon University.

   At Present, Nicki is pursuing a Doctor of Philosophy (PhD) in Counseling Schooling and Supervision at Grand Canyon College.
   Nicki’s research interests embody the use
   of Constructive Psychology interventions with dual
   diagnosis shoppers. Nicki hopes to contribute to the physique
   of knowledge in treating substance use issues. These long-term effects can have an effect on an individual’s daily life and make it
   troublesome for her or him to work, have relationships,
   and even perform regular activities.
   We can even consider metabolites on account
   of converting one chemical compound into another.
   So, while it’s pointless to be a chemistry expert to know that metabolites are a key
   consider any steroid drug testing, it would be finest to understand how long these metabolites can stay
   in your system. The extra advanced scientific evaluation strategies now obtainable made this
   attainable – and it sends an alarm out to anybody who
   thinks a unfavorable end result now means you’re in the clear eternally.
   Testers will normally test for all identified steroids,
   but when assets are restricted, then solely the most generally used steroids shall be tested for.
   As A Outcome Of the testing has to focus on a specific steroid, the method
   should include each potential steroid to cover all bases.
   One of the most significant monetary risks of buying steroids is when you don’t receive
   them; you either obtain fakes or get nothing.
   The misuse of anabolic steroids is common among athletes because it will increase lean muscle mass extra rapidly and dramatically when mixed with weight lifting than weight lifting alone.
   Many people who take it deal with a body dysmorphic disorder referred to
   as muscle dysmorphia, which is a preoccupation with
   muscle dimension and the concern that muscular tissues are too small.
   They can even assist lower estrogen ranges,
   which can help treat estrogen receptor optimistic
   breast most cancers by blocking the growth of cancer cells that use estrogen to grow.
   For folks with cancer or AIDS who are dropping muscle, anabolic steroids improve the
   variety of androgen receptors in skeletal muscle and increase it in size and power.

   Anabolic steroids are medication made in a lab that
   mimic the naturally occurring male intercourse hormones
   known as androgens. Some athletes, bodybuilders and others misuse these drugs in an try to enhance efficiency and/or enhance their bodily appearance.

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9. Some SARM compounds can ship noticeable adjustments inside about 4 weeks,
   whereas others can take as long as eight weeks to kick in and have you ever noticing the advantages.
   SARMs, subsequently, require a longer-term method to their use,
   however on the upside, they don’t include the identical
   drastic unfavorable effect in your hormonal system and total well being that steroids do.
   When it comes to the World Anti-Doping Company and different skilled sporting authorities
   around the world, SARMs are banned in the same method that anabolic steroids and all other performance-enhancing drugs
   are. Theoretically, SARMS shouldn’t show a lot of the adverse effects of steroids because of
   their strict tissue selectivity. But as a end result of SARMs are not but perfected, we are ready to and do
   experience a number of the undesirable unwanted effects that you’d in any other case try to keep away from by not utilizing anabolic steroids.

   An 8-week cycle is enough for achieving excellent fats loss results, with a toned, defined, and muscular physique
   achievable over these two months. Ideally, you’ll start the cycle at a low dose,
   gauge your response, and slowly enhance the dose all through the cycle.

   The length of these cycles can vary depending on the sort of steroid used, the specified outcomes,
   and the way your physique responds to those substances. A survey by the National Institute on Drug Abuse found that round 1 million individuals within the
   Usa have used anabolic steroids sooner or later in their lives, with 22% of these users
   starting before the age of 20. This is concerning, contemplating that the American Academy of Pediatrics
   strongly discourages the use of performance-enhancing substances in youth, due to the potential for serious well being dangers.
   Steroids have been part of health history since the
   golden era of bodybuilding.
   Even wholesome individuals are at risk when using steroids with out correct oversight.
   When considering testosterone replacement therapy (TRT) or anabolic
   steroids, it is important to understand who these remedies are designed for and why they might be
   used. Both have specific purposes, and choosing between them—or deciding whether or not either is appropriate—depends on particular person circumstances,
   objectives, and medical advice. Testosterone alternative remedy is primarily used to treat men with low
   testosterone ranges as a outcome of medical situations like hypogonadism or growing older.

   Physicians in the US usually are not allowed to prescribe these medicine for non -medical functions.

   Nonetheless, their illegal use continues even though
   the sporting career of those sportsmen could be irrevocably destroyed if caught.
   Progestins are steroid hormones which are typically prescribed to postpone warmth cycles or alleviate false
   pregnancies in female canine and treat benign prostatic hypertrophy in male canine.
   They may be used for some kinds of pores and skin issues or
   to change aggressive habits. Megestrol acetate and medroxyprogesterone are the most generally used progestins in canine.

   It is a killer combo, with Primo included, because of the standard gains it delivers.
   You won’t be placing a lot size on with this stack, but it’s excellent for slicing.
   The Deca will profit you from therapeutic improvements, particularly joint healing24.
   Combining Anavar and Primo will deliver the hard physique you’re after and might even be extra forgiving in case your food plan isn’t
   excellent. You’ll also be able to keep muscle more easily (Primo doesn’t aromatize), but remember, this isn’t an affordable cycle to run.
   While orals are easier to take, they arrive with toxic side effects to the
   liver. This interval is perfect because it lets
   you make gains for the longest time till you attain the purpose the place gaining muscle
   starts to decrease, plateau, and doubtlessly cease altogether.
   This eliminates any losing of time (and steroids) if
   your physique isn’t going to make gains – as
   a substitute allowing you to go off cycle and clear your
   system in preparation for the beginning of the following cycle.
   This will depend on a quantity of elements, but the principle ones are which steroid
   compound (or compounds) you wish to use and your general goals (plus when you
   expect to be confronted with any drug testing at any stage).
   Cycling requires a plan19, as you’ll resolve how lengthy you need to take
   the steroid and the way long the break in between will be when you cease utilizing it.

   The course of is monitored by a health care provider, who checks for unwanted side effects and adjusts therapy as wanted.
   This medical supervision is essential because it helps cut back risks and ensures
   the remedy is working as supposed. There are limited medical
   uses for anabolic steroids, such as treating extreme muscle loss from sure illnesses.
   Nevertheless, most non-medical use entails doses far greater than what
   medical doctors would prescribe. TRT focuses on restoring normal testosterone ranges and
   improving overall well being. Its benefits are gradual
   and long-term, aiming to deal with deficiencies that negatively have an effect on daily life.

   More-dangerous kinds of anabolic steroids are called
   designer steroids. Anabolic steroids have no medical use that is approved by the government.
   These drugs would possibly decrease the harm that
   occurs to muscles during a tough exercise.
   For instance, anabolic steroids, which are sometimes used
   to enhance athletic efficiency, can lead to liver damage,
   coronary heart problems, and an elevated threat of stroke and heart attack.

   In truth, based on the World Health Organization, the misuse
   of anabolic steroids can have critical penalties for both physical and psychological
   health, together with infertility, temper swings, and aggression. This
   is why it’s important to work on restoring the
   pure hormone steadiness after using AAS compounds.

   In some circumstances, like when you’re working a cycle for contest prep, extra particular changes are wanted to
   meet a objective. Nonetheless, most guys will stick to an identical program with minor modifications through the cycle compared to when off-cycle.
   For this mix, you won’t require a SERM, and you will probably find higher libido well being as well because Masteron encourages DHT, which boosts the
   libido but acts as an estrogen control. This makes Masteron a compound that fits this
   technique perfectly, perhaps greater than some other compound, particularly if retaining the libido is
   essential to you.

   References:

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10. With the exception of its effect on Lp(a), AAS use – especially use of 17α-alkylated AAS – results in a extra atherogenic lipid profile (see
    Table 1). This might help explain the outcomes of a population-based cohort research during which males that tested constructive for AAS had twice the cardiovascular morbidity and mortality fee as those who tested adverse (149).
    However, it should be acknowledged that causality can’t be
    drawn from such studies and additional analysis is
    important to better explore this detrimental avenue of
    AAS use on Bruce Lee Health Products.
    A trial in older hypogonadal men randomized to
    TRT with or without the 5α-reductase inhibitor dutasteride famous no change in CEC (137).
    CEC additionally remained unchanged in transgender males
    (female to male) present process treatment with testosterone gel or injections (138).

    In distinction, cross-sectional analysis demonstrated
    impaired CEC in AAS users compared with age-matched, strength-trained nonusers and sedentary controls
    (139).
    These compounds can considerably increase testosterone ranges, making them engaging to us for
    bodybuilding. This time frame also reduces unwanted facet
    effects, although this can heavily rely upon what compounds
    you’re using. Medium cycles restrict you from making the positive aspects you
    want during these few weeks, so you’ll be pretty restricted to
    faster-acting compounds. Testosterone Propionate is usually
    the ester of selection for a medium cycle. In Contrast To biking, where you may
    abruptly cease using steroids entirely on the finish of a
    cycle, pyramiding allows you to taper off slowly.

    I am a muscular man with a lot attention and recognition for my physique.
    I started with little or no and all the time put 110% into the fitness center to get to where I
    am now. From anabolic steroids to SARMs to peptides and ancillary
    medicine, I’ve done it in some unspecified
    time within the future in my life, and I can relate. There could
    be a lot of misunderstanding about how drug testing
    for steroids and performance-enhancing medication works. Many assume it’s a simple matter of supplying a urine (or
    blood) sample, having the sample despatched to a lab, and being put through a machine that magically detects each
    substance.
    One distinctive advantage that has been documented in analysis is that Anavar decreases visceral and
    subcutaneous fat ranges. Testosterone is typically administered via intramuscular
    injection; however, it’s also obtainable in oral form, generally recognized as testosterone undecanoate or Andriol
    (Testocaps). We have found that a SERM could additionally be a more
    sensible choice than an AI (aromatase inhibitor), because the latter can worsen blood lipids,
    rising the risk of hypertension. Anadrol, like Superdrol, may be very hepatotoxic, inflicting excessive AST (aspartate transaminase) and ALT (alanine transaminase) levels in research (3).
    Our sufferers have efficiently decreased hepatic injury by supplementing with TUDCA (tauroursodeoxycholic acid).
    Nonetheless, not every bodybuilder is fond of needles,
    and if AAS are incorrectly administered through intramuscular injection, it can end result in paralysis or dying (1).

    Whether Or Not you are looking for testosterone, progesterone, anabolic steroids, or some other steroid merchandise, we could
    have what you want. We stock many merchandise in all types including liquid, capsule, injections, transdermal, implants, and trenbolone acetate
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    Two studies were recognized on this evaluate the place people who discontinued AAS use needed treatment for subsequent psychiatric signs including melancholy and suicidal ideation [87, 89].
    A further 11 studies reported therapies for neuroendocrine problems,
    primarily with males who had discontinued their AAS use previous
    to the onset of signs.
    One research showed that ex-steroid users had much less subcutaneous fats mass,
    presumably due to the fat-burning effects of
    steroids. Chris was known to have used anabolic steroids,
    together with his body containing 10 instances more testosterone than the traditional degree on the scene of the
    crime (30). However, different theories suggest brain harm or extreme alcohol consumption might have also contributed
    to this tragedy. Bodybuilders often complement with
    fish oil to try to negate this aspect effect; nonetheless, this methodology isn’t confirmed to be efficient.
    Fish oil, even with out the presence of anabolic steroids, has been found ineffective in decreasing
    systolic blood stress in regular middle-aged males (7, 8).
    Furthermore, people report that anabolic steroids
    (like Dianabol) can be bought in Thailand for a fraction of the
    price compared to the US and UK, causing many bodybuilders to take steroid holidays to this a
    half of Asia.
    A review of the analysis means that about 32 percent of folks that misuse anabolic steroids turn out to be dependent forty three.
    Symptoms of dependence can embody tolerance, which is needing
    to take extra steroids to attain the same effects. Another indicator of dependence is withdrawal once
    anabolic steroid use stops forty two. Withdrawal signs can embody fatigue, restlessness,
    lack of appetite, insomnia, reduced sex drive, and steroid cravings 44.
    The most harmful of the anabolic steroid withdrawal signs is depression, as a result of it generally leads to suicide attempts forty five.
    Anabolic steroid customers are generally used
    by athletes in any respect levels in sports similar
    to bodybuilding, weightlifting, baseball, football, cycling,
    wrestling, and lots of others to improve their efficiency.
    Usually, it is males of their mid to late 30’s who
    use anabolic steroids non-medically the most eleven.
    Oral steroids will value you between $50 and $100 for a bottle of a hundred capsules.
    You will find that lots of bodybuilders will observe two months on, one-month off-cycle sample.
    It also supplies you with the opportunity to stay emotionally and mentally refreshed.
    It is extremely necessary to know that a steroid cycle is not going
    to work in isolation.
    It is amongst the least androgenic steroids, making it
    a top choose for these wanting muscle positive aspects without extreme unwanted effects.
    IGF-1 has been linked to more muscle gain, more fat loss, higher hair, higher pores
    and skin, higher high quality of life, better sleep, and even a better
    sexual life. The main objectives of medication-assisted remedy are to assist alleviate withdrawal symptoms,
    forestall relapse, and restore hormonal steadiness.

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11. Nandrolone decanoate and nandrolone phenpropionate are both known for his or her increased ratio of anabolic
    exercise in comparability with androgenic activity.
    Nandrolone decanoate is a slow-acting anabolic steroid that is particularly designed to extend muscle
    mass. It works by promoting nitrogen retention in muscular
    tissues, which leads to a rise in muscle dimension.
    This estimate does not accurately replicate the actual androgen exposure, due to the reality that it’s primarily based on the declared and never the precise focus of the abused products.
    Furthermore, it combines oral and injectable merchandise and several types of androgens.
    Nonetheless, it provides a sign that the weekly
    dose varies enormously between customers and that the imply
    dose is very supraphysiologic. For comparability, a traditional substitution dose of an injectable
    testosterone-ester to deal with male hypogonadism shouldn’t exceed a hundred mg per week
    (6).
    There is drastically increased issue for physicians
    when dealing with other anabolic steroids since nearly all of
    them are not sanctioned for medical functions or even human use.
    Nevertheless, there is a massive growing population who has used
    or continues to make use of these agents. This creates the necessity for a larger understanding of those drugs, especially in the
    context of screening for opposed well being effects. Throughout the present time,
    there isn’t a formal evidence-based steering on screening anabolic steroid users for varied pathologies.
    Physicians are more probably to rely on national screening
    pointers due to the lack of proof on primary prevention in this patient inhabitants.
    Elevated recognition of AAS and improved data of this patient population is essential, particularly on circumstance that over 1 million People
    have used anabolic steroids [4]. It outcomes from distortion of the
    androgen-estrogen stability during or after administration of AAS.

    Withdrawal symptoms can include fatigue, restlessness, loss
    of urge for food, insomnia, lowered sex drive, and steroid cravings forty four.
    The most harmful of the anabolic steroid withdrawal symptoms is
    depression, because it typically leads to suicide attempts forty five.
    Anabolic-androgenic steroids (AAS) are a synthetic type of testosterone used to extend muscle mass
    and strength. They may be harmful and cause unwanted effects,
    and the risks generally outweigh any benefits.
    Despite the big number of articles identified, the proof base consists of
    case reviews of predominantly treatment of physiological harms and there is scarce evidence on treating
    dependence, managing withdrawal, or initiating behaviour change in customers in any
    settings. Evidence is urgently required to support the event
    of efficient companies for users and of evidence-based
    steerage and interventions to answer users in a variety of healthcare settings.
    More constant reporting in articles of whether engagement or
    evaluation referring to AAS was initiated, and publication within broader health- or drug-related journals, will support development of the evidence base.
    This scoping evaluation indicates that while a spread of case stories describe
    therapies offered to AAS customers, there could be scarce evidence on treating dependence,
    managing withdrawal, or initiating behaviour change in users
    in any settings. The perform of the transcriptional activation domains on the receptor is to mediate the binding of
    the receptor to the comodulators. The receptor has
    an N-terminal activation function-1 (AF-1) and a second activation function-2 (AF-2) in the C-terminal ligand-binding area.
    The mechanisms of AF-1 and AF-2 gene activation, with emphasis on AF-1 and AF-2 conformation and co-activator binding, have been reviewed
    by Warnmark et al. (2003).
    For example, a study of 227 males admitted in 1999 to a personal therapy middle for habit to heroin or different opioids found that 9.three % had previously misused anabolic steroids 142.
    Of these, most reported utilizing opioids to counteract insomnia,
    irritability, melancholy, and withdrawal from
    anabolic steroids 142. Anabolic steroid customers are extra doubtless to make use of drugs
    corresponding to marijuana, prescription opioids, cocaine, or heroin 138, 139.
    In a research of males admitted to therapy for opioid use disorders, 25 percent reported prior use of anabolic steroids.

    Gynecomastia usually develops during puberty, with a reported peak
    incidence of 65% in 14-year-old boys (198). The condition stays
    prevalent all through adulthood, with one study reporting gynecomastia in 40.5%
    of healthy younger men aged 18–26 years (199)
    and another reporting detectable palpable breast tissue in 36% of healthy adult men aged 16–58 years (200).
    While palpable, in the great majority of circumstances the gynecomastia was small in size.

    Initially, titles and abstracts for all articles recognized had been reviewed
    against the inclusion standards by one reviewer. The full texts for all articles included at this
    stage were retrieved and subjected to additional screening in opposition to inclusion standards.
    There has been a fourfold enhance in the variety of English language academic papers printed between 1995
    and 2015 [59]. Nonetheless, there remains scant proof in relation to efficient policy and practice inside the topic.

    Whereas we have a greater understanding of the environmental influences and risk components for use
    [17, 60–62], there are few robust findings to assist the efficient prevention of AAS use.

    In the canonical Notch pathway, the binding of ligands to
    the Notch receptor causes the translocation of
    the Notch intracellular area (NICD) to the cytoplasm, wherein it undergoes sequential enzymatic cleavage and translocates to the cell
    nucleus (12, 21). Here, it binds to a CSL transcription issue forming a certain complex which then activates the
    transcription of target genes similar to Hes and Hey
    (12, 21). As it’s crucial to satellite cell activation and proliferation, this
    pathway plays an integral role in tissue morphogenesis and the restore of
    SM (21, 22). The goal of this examine was to compare the
    reproductive hormone levels and symptoms suggestive of hypogonadism in young males with
    histories of current and former AAS abuse with these of healthy age-matched males.

    This scoping evaluation of the literature has identified therapies given to AAS customers for a variety of physiological and psychological harms.

    References:

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